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The Krishnan Lau lab is seeking highly motivated research technicians to join our research team in the department of Biochemistry & Cellular and Molecular Biology. Our research goals focus on identifying the molecular, cellular and neural mechanisms underlying typical behavior and neuropsychiatric disorders. We use an integrative approach that includes molecular tools, whole-brain histological analyses and behavioral assays to understand brain functions in ethologically-relevant behaviors as well as behavioral paradigms that aim to test specific sensory modality, of both healthy mice and mouse models of neuropsychiatric disorders. Perform wet-lab experiments: Learn and perform cellular, and histological laboratory techniques to support ongoing neuroscience research projects. Responsibilities may include sectioning, immunohistochemistry and immunofluorescence staining; PCR and genotyping Follow established protocols carefully, maintain detailed and accurate experimental records, troubleshoot technical challenges, and assist with the optimization and development of experimental procedures. Perform animal work and behavioral assays: Learn and assist with the day-to-day management and maintenance of laboratory mouse colonies, including genotyping, and record keeping. Learn and assist with a variety of mouse behavioral assays designed to assess sensory, cognitive, emotional, social, and/or ethologically relevant behaviors. Conduct animal procedures in accordance with approved IACUC protocols, institutional policies, and applicable animal welfare regulations.
Perform microscopy analyses and image analyses: Prepare biological samples for microscopic examination and acquire high-quality images using epifluorescence and confocal microscopy. Optimize imaging parameters and acquisition settings to obtain reproducible and quantitatively reliable datasets. Perform image processing and quantitative analyses of cellular, anatomical, and molecular markers using appropriate image-analysis software. Assist with the development and application of standardized image-analysis workflows, maintain organized imaging datasets and metadata.
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